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Prague airport is quite far from the city centre but easily reachable using public transport that can take you there in about 30 minutes. You can catch a taxi or use the public transport and take the bus. There is no metro going to the airport but there should be fast train line in the future.
There are several bus lines from Prague airport to the city centre. The ticket costs 42 Kč and is valid for 90 minutes in buses, trams and metro across the whole Prague. Bus stations are right in front of the airport terminals and you can catch following buses there:
Uber is the official provider of taxis from the airport. The ride costs about 750 Kč from airport to the city centre and takes about 30 minutes depending on the traffic. You can order the Uber taxi using the mobile application, in the special self-service kiosks located near airport exits or by service counter with assistant.